GENFI has developed a number of clinical scales for use as outcome measures in trials.
NM module (to be added to CDR plus NACC FTLD)
The NM module includes the neuropsychiatric and motor symptom domains developed to be additions to the standard CDR plus NACC FTLD scale. It does not modify the original scales (CDR or NACC FTLD module) but can be used to extend the phenotype measured by those scales.
The original publications outlining this work are here:
- Samra K, MacDougall AM, Peakman G et al. Motor symptoms in genetic frontotemporal dementia – developing a new module for clinical rating scales. J Neurol. 2023;270(3):1466-1477.
- Samra K, MacDougall AM, Peakman G et al. Neuropsychiatric symptoms in genetic frontotemporal dementia – developing a new module for clinical rating scales. J Neurol Neurosurg Psychiatry. 2023;94(5):357-368.
- Samra K, Peakman G, MacDougall AM et al. Extending the phenotypic spectrum assessed by the CDR® plus NACC FTLD in genetic frontotemporal dementia. Alzheimers Dement (Amst). 2024;16(2):e12571.
The NM module can be found here.
A scoring module for the CDR plus NACC FTLD-NM can be found here.
We are currently developing a training session for this – please email if you have further questions.
FTD module (to be added to NPI)
The FTD module was developed to be an addition to the original Neuropsychiatric Inventory scale.
The original publication outlining the work is here:
Jiskoot LC, Russell LL, Greaves CV et al. Addition of the FTD Module to the Neuropsychiatric Inventory improves classification of frontotemporal dementia spectrum disorders. J Neurol. 2023;270(5):2674-2687.
The FTD module can be found here and a scoring module here.
CBI-R
We have developed a scoring module for the revised version of the Cambridge Behavioural Inventory which maps to bvFTD behavioural domains. This can be found here.
FRS
We have additionally developed a scoring module for the FTD Rating Scale (FRS). This can be found here.
Using these clinical scales in other studies
If you are interested in using the clinical scales in your study please email us at genfi@ucl.ac.uk.