GENFI has helped developed a number of clinical scales that we hope will help in measuring change in trials.
NM module (to be added to CDR plus NACC FTLD)
The NM module includes the neuropsychiatric and motor symptom domains developed to be additions to the standard CDR plus NACC FTLD scale. It does not modify the original scales (CDR or NACC FTLD module) but can be used to extend the phenotype measured by those scales.
The original publications outlining this work are here:
- Samra K, MacDougall AM, Peakman G et al. Motor symptoms in genetic frontotemporal dementia – developing a new module for clinical rating scales. J Neurol. 2023;270(3):1466-1477.
- Samra K, MacDougall AM, Peakman G et al. Neuropsychiatric symptoms in genetic frontotemporal dementia – developing a new module for clinical rating scales. J Neurol Neurosurg Psychiatry. 2023;94(5):357-368.
- Samra K, Peakman G, MacDougall AM et al. Extending the phenotypic spectrum assessed by the CDR® plus NACC FTLD in genetic frontotemporal dementia. Alzheimers Dement (Amst). 2024;16(2):e12571.
The NM module can be found here.
We are currently developing a training session for this – please email if you have further questions.
FTD module (to be added to NPI)
The FTD module was developed to be an addition to the original Neuropsychiatric Inventory scale.
The original publication outlining the work is here:
J Neurol. 2023;270(5):2674-2687.
The FTD module can be found here.